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  • MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

    Authors
    Wei, Qiaozhi
    Frenette, Paul S.
    Description

    Summary from the GEO: "Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood cells during the entire lifetime. The mechanisms by which these critical activities are balanced are still unclear. Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island1,...

    Subject
    Cell Adhesion Molecules
    Cytoskeletal Proteins
    Gene Expression Profiling
    Hematopoiesis
    Hematopoietic Stem Cells
    Leukemia, Myeloid, Acute
    Lymphokines
    Ubiquitin-Protein Ligases
    Access Rights
    Free to All
  • RNA-seq for UBR5-regulated genes in tumor associated macrophages

    Authors
    Song, Mei
    Zhang, Tuo
    Description

    Summary from the GEO: "RNA-seq analysis of peritoneal macrophages derived from non-tumor bearing, WT ID8 tumor-bearing, and Ubr5 KO ID8 tumor bearing C57BL/6 mice." From the publication abstract: "Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular...

    Subject
    Macrophages, Peritoneal
    Ovarian Neoplasms
    Ubiquitin-Protein Ligases
    Access Rights
    Free to All